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Exaudi Staff

Analysis

20 November, 2025

2 min

A natural approach that challenges assisted reproduction!

Spanish study with over 1,300 couples reveals 62% success rates of babies brought home without in vitro fertilization

A natural approach that challenges assisted reproduction!
Alexandr Podvalny . Unsplash

While millions of couples worldwide resort to expensive and complex assisted reproductive treatments like IVF (in vitro fertilization), a specialized center in Spain is demonstrating that restoring the body’s natural fertility can be just as effective—or even more so—in many cases. A new study published in the journal Frontiers in Reproductive Health analyzes the results of Natural Procreative Technology (NaProTechnology or NPT)  in 1,310 infertile couples treated over five years at the Fertilitas Center in Madrid.

The numbers speak for themselves:  35.3% of couples successfully conceived without adjustments, but when adjusted for the length of time they remained in treatment, the rate rises to an impressive 62.1%. In women under 30, the adjusted success rate approaches 84%, while in the 36-40 age group, it remains above 53%.

What exactly is NaProTechnology? Far from being an “alternative” method without a scientific basis, NPT is a comprehensive medical approach that teaches couples to interpret the natural biomarkers of fertility (through the Creighton Model) and, from there, diagnose and treat the underlying causes of infertility: hormonal imbalances, endometriosis, adhesions, ovulation problems, or male factors. It includes everything from hormonal supplements and antibiotics to minimally invasive surgeries when necessary, always aiming for conception to occur naturally within the woman’s body.

“Many patients come to us after several failed IVF cycles and with an average age of 35, which isn’t exactly the most favorable,” explains Dr. José Ignacio Sánchez-Méndez, lead author and director of Fertilitas. “Even so, we manage to help more than six out of ten couples achieve their goal without the risks associated with assisted reproduction, such as multiple pregnancies or neonatal complications.”

Among the most striking findings:

  • 85.6% of the couples presented treatable hormonal disorders.
  • 30.6% required surgery (mainly hysteroscopy or laparoscopy), which was performed in an average time of only 6 months.
  • 72% of pregnancies were achieved in the first year of treatment.
  • Factors such as endometriosis or recurrent pregnancy loss, far from being insurmountable obstacles, were paradoxically associated with greater chances of success once treated.

The authors emphasize that TPN is not only effective, but also safer and more ethical for many couples who reject the embryo creation and discarding inherent in IVF. Furthermore, its cost is significantly lower and could alleviate pressure on public healthcare systems, where waiting lists for assisted reproduction treatments can exceed two years.

Although it is a single-center, retrospective study, it is one of the largest conducted to date using this methodology and opens the door to multicenter research directly comparing TPN with IVF in similar populations.

For the thousands of couples struggling with infertility in Spain and around the world, this work represents a ray of hope: sometimes, the solution is not in “manufacturing” life in a laboratory, but in helping the body recover its natural ability to conceive.

New study by FERTÍLITAS / New scientific evidence of NaProTechnology / The world’s largest peer-reviewed study / Access via the link.

Exaudi Staff

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